Nerve Transfers to Restore upper Extremity Function: A Paradigm Shift

Brachial plexus and peripheral nerve injuries lead to significant upper extremity dysfunction and disability. Traditionally, both have been treated with nerve grafting when a tensionless, end-to-end repair is not feasible. Despite our best efforts, functional outcomes of this procedure are less than ideal due to the long distances that the axons must regenerate to reach their end organs. Over the past 20 years our understanding of nerve anatomy, topography, and regeneration has improved and the surgical technique of nerve transfers has been developed. Due to improved functional outcomes, decreased morbidity, and surgical time, we are now experiencing a paradigm shift in the treatment of brachial plexus and peripheral nerve injuries from nerve grafting to nerve transfers (1, 2). Motor function after nerve injury is dependent on both time to reinnervation and the number of motor axons reinnervating the target muscle (3). Nerve transfers capitalize on these two factors and are the reason for their clinical success. Nerve transfers, by definition, involve coapting a healthy, expendable donor nerve or fascicle to a denervated recipient nerve to restore function to the recipient end-organ (skin for sensation or muscle for motor function). They can be performed closer to the recipient target allowing for earlier reinnervation of the muscle and quicker return of function. Further advantages include that nerve transfers are performed outside the zone of injury and scarred field, can be performed on patients with delayed presentation, and can avoid interpositional nerve grafting, which leads to increased numbers of regenerating nerve fibers making it to the target organ (3). The ideal timing of nerve transfers has not yet been established, but reinnervation of the muscle by 12–18 months after injury is a common goal. Indications are evolving and currently include patients with proximal nerve root avulsions, high level peripheral nerve injuries, large neuromasin-continuity, and/or multi-level nerve injuries. In our group, we use nerve transfers to treat most brachial plexus injuries (avulsions or not) and peripheral nerve injuries in upper arm or proximal forearm. We usually reserve nerve grafting for nerve injuries in the distal forearm or hand because the regenerative distances and time to reinnervation of the muscle are short. At these distal injuries, functional outcomes with grafting are similar to those seen with nerve transfers and donor site morbidity from a nerve transfer is avoided. In brachial plexus injuries, a hierarchy of return of function exists with efforts directed to restoring elbow flexion first, followed by shoulder function, then hand function. For upper trunk injuries, multiple combinations of nerve transfers have been described. The double fascicular nerve transfer is the most common nerve transfer performed to return elbow flexion. This transfer involves coapting redundant nerve fascicles from the median and ulnar nerves to the biceps brachii and brachialis branches of the musculocutaneous nerve. Many have reported their experience with this transfer and patients have achieved at least Medical Research Council (MRC) strength of 3 with most achieving grade 4 or greater without evidence of donor site morbidity (4–6). For restoration of shoulder function transfers of the spinal accessory nerve to the suprascapular nerve and a branch of the triceps to the axillary nerve are most commonly performed. Thoracodorsal nerve and intercostal nerves transferred to the long thoracic nerve are also common to restore scapular stability provided by the serratus anterior muscle. Restoration of shoulder abduction and external rotation has been successfully reported with these nerve transfers (7, 8). In lower plexus injuries, the brachialis branch of the musculocutaneous nerve can be transferred with encouraging results to the anterior interosseous nerve to restore prehension. Previously, these lower plexus injuries were treated with free functional muscle transfers given the great regenerative distance from the brachial plexus to the forearm musculature. However, free functional muscle transfers are associated with increased morbidity, operative time, and lengthy hospital stays. The brachialis to anterior interosseous nerve transfer avoids these drawbacks and establishes a platform for restoring function to the hand. In addition to their use for brachial plexus injuries, nerve transfers to restore hand function following peripheral nerve injuries are also gaining momentum. New transfers continue to be developed as our understanding of nerve topography grows. Ulnar nerve injuries result in loss of power grip, pinch strength, and hand dexterity. The pronator quadratus branch of the anterior interosseous nerve can be transferred to the motor component of the ulnar nerve distally in the forearm to reinnervate the intrinsic muscles of the hand (9). It was originally described as an end-toend coaptation if no regeneration of the ulnar nerve is expected, but recently Mackinnon and colleagues have shown efficacy of an end-to-side “supercharge” coaptation enabling proximal regeneration of the ulnar nerve to proceed as well (10). Upper extremity trauma frequently results in radial nerve injuries impairing both